RAB3A anticorps (AA 100-200)

N° du produit ABIN7269809

L’anticorps Lapin Polyclonal anti-RAB3A a été validé pour WB et IF. Il convient pour détecter RAB3A dans des échantillons de Humain.

Aperçu rapide pour RAB3A anticorps (AA 100-200) (ABIN7269809)

Antigène: RAB3A (RAB3A, Member RAS Oncogene Family (RAB3A))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RAB3A est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-RAB3A anticorps

Épitope: AA 100-200

Fonction: RAB3A Rabbit pAb

Séquence: LMYDITNEES FNAVQDWSTQ IKTYSWDNAQ VLLVGNKCDM EDERVVSSER GRQLADHLGF EFFEASAKDN INVKQTFERL VDVICEKMSE SLDTADPAVT G

Réactivité croisée: Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: A synthetic peptide corresponding to a sequence within amino acids 100-200 of human RAB3A (NP_002857.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur RAB3A

Antigène: RAB3A (RAB3A, Member RAS Oncogene Family (RAB3A))

Autre désignation: RAB3A

Sujet: Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity. Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity. Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By similarity. Stimulates insulin secretion through interaction with RIMS2 or RPH3AL effectors in pancreatic beta cells (By similarity. Regulates calcium-dependent lysosome exocytosis and plasma membrane repair (PMR via the interaction with 2 effectors, SYTL4 and myosin-9/MYH9. Acts as a positive regulator of acrosome content secretion in sperm cells by interacting with RIMS1. Plays also a role in the regulation of dopamine release by interacting with synaptotagmin I/SYT (By similarity. Interacts with MADD (via uDENN domain, the GTP-bound form is preferred for interaction (By similarity.,RAB3A,Signal Transduction,G protein signaling,Signal Transduction,RAB3A

Poids moléculaire: 24kDa

ID gène: 5864

UniProt: P20336

Pathways: Synaptic Membrane, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport