RPSA/Laminin Receptor anticorps

N° du produit ABIN7270042

Cet anticorps Lapin Monoclonal détecte spécifiquement RPSA/Laminin Receptor dans WB et IF. Il présente une réactivité envers Humain.

Aperçu rapide pour RPSA/Laminin Receptor anticorps (ABIN7270042)

Antigène: RPSA/Laminin Receptor (RPSA) (Ribosomal Protein SA (RPSA))

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp RPSA/Laminin Receptor est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-RPSA/Laminin Receptor anticorps

Fonction: 67kDa Laminin Receptor Rabbit mAb

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Monoclonal Antibodies

Purification: Affinity purification

Immunogène: A synthesized peptide derived from human 67kDa Laminin Receptor

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur RPSA/Laminin Receptor

Antigène: RPSA/Laminin Receptor (RPSA) (Ribosomal Protein SA (RPSA))

Autre désignation: RPSA

Sujet: Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008],37LRP, 67LR, ICAS, LAMBR, LAMR1, LBP, LBP/p40, LRP, LRP/LR, NEM/1CHD4, SA, lamR, p40,Angiogenesis,Cardiovascular,Cell Adhesion,Cell Biology & Developmental Biology,Cytoskeleton,Cytoskeleton_Intermediate Filaments,Extracellular Matrix,Neurodegenerative Diseases,Neuroscience,Signal Transduction,RPSA

Poids moléculaire: 42kDa

ID gène: 3921

UniProt: P08865

Pathways: Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly