TBC1D4 anticorps (pSer588)

N° du produit ABIN7270747

Cet anticorps Lapin Polyclonal détecte spécifiquement TBC1D4 dans WB. Il présente une réactivité envers Humain.

Aperçu rapide pour TBC1D4 anticorps (pSer588) (ABIN7270747)

Antigène: TBC1D4 (TBC1 Domain Family, Member 4 (TBC1D4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TBC1D4 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-TBC1D4 anticorps

Épitope: pSer588

Fonction: Phospho-TBC1D4-S588 Rabbit pAb

Séquence: LGSVD

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Phosphorylated Antibodies

Purification: Affinity purification

Immunogène: A synthetic phosphorylated peptide around S588 of human TBC1D4 (NP_055647.2).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur TBC1D4

Antigène: TBC1D4 (TBC1 Domain Family, Member 4 (TBC1D4))

Autre désignation: TBC1D4

Sujet: This gene is a member of the Tre-2/BUB2/CDC16 domain family. The protein encoded by this gene is a Rab-GTPase-activating protein, and contains two phopshotyrosine-binding domains (PTB1 and PTB2), a calmodulin-binding domain (CBD), a Rab-GTPase domain, and multiple AKT phosphomotifs. This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4), important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane, suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions. When exposed to insulin, this protein is phosphorylated, dissociates from GLUT4 vesicles, resulting in increased GLUT4 at the cell surface, and enhanced glucose transport. Phosphorylation of this protein by AKT is required for proper translocation of GLUT4 to the cell surface. Individuals homozygous for a mutation in this gene are at higher risk for type 2 diabetes and have higher levels of circulating glucose and insulin levels after glucose ingestion. Alternative splicing results in multiple transcript variants encoding different isoforms.,AS160,NIDDM5,TBC1D4,Signal Transduction,G protein signaling,Signal Transduction,PI3K-Akt Signaling Pathway,Endocrine & Metabolism,Insulin Receptor Signaling Pathway,Protein phosphorylation,TBC1D4

Poids moléculaire: 53kDa/60kDa/139kDa/145kDa/146kDa

ID gène: 9882

UniProt: O60343