Tppp anticorps

N° du produit ABIN7271031

Détail du produit anti-Tppp anticorps

Antigène: Tppp (Tubulin Polymerization Promoting Protein (Tppp))

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp Tppp est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Fonction: TPPP/p25 Rabbit mAb

Réactivité croisée: Souris, Rat

Attributs du produit: Monoclonal Antibodies

Purification: Affinity purification

Immunogène: A synthesized peptide derived from human TPPP/p25

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur Tppp

Antigène: Tppp (Tubulin Polymerization Promoting Protein (Tppp))

Autre désignation: TPPP (Tppp Produits)

Synonymes: anticorps TPPP/p25, anticorps TPPP1, anticorps p24, anticorps p25, anticorps p25alpha, anticorps 2900041A09Rik, anticorps AI849835, anticorps RGD1310121, anticorps tubulin polymerization promoting protein, anticorps TPPP, anticorps Tppp

Sujet: Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath. Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath. Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes. Shows magnesium-dependent GTPase activity, the role of the GTPase activity is unclear. In addition to microtubule nucleation activity, also involved in microtubule bundling and stabilization of existing microtubules, thereby maintaining the integrity of the microtubule network. Regulates microtubule dynamics by promoting tubulin acetylation: acts by inhibiting the tubulin deacetylase activity of HDAC6. Also regulates cell migration: phosphorylation by ROCK1 inhibits interaction with HDAC6, resulting in decreased acetylation of tubulin and increased cell motility. Plays a role in cell proliferation by regulating the G1/S-phase transition. Involved in astral microtubule organization and mitotic spindle orientation during early stage of mitosis, this process is regulated by phosphorylation by LIMK2.,TPPP/p25, TPPP1, p24, p25, p25alpha,Cell Biology & Developmental Biology,Cytoskeleton,Cytoskeleton_Microtubules,Signal Transduction,TPPP

Poids moléculaire: 25kDa

ID gène: 11076

UniProt: O94811