UBE2O anticorps (AA 1073-1292)

N° du produit ABIN7271180

L’anticorps Lapin Polyclonal anti-UBE2O a été validé pour IHC. Il convient pour détecter UBE2O dans des échantillons de Humain.

Aperçu rapide pour UBE2O anticorps (AA 1073-1292) (ABIN7271180)

Antigène: UBE2O (Ubiquitin-Conjugating Enzyme E2O (UBE2O))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UBE2O est non-conjugé

Application: Immunohistochemistry (IHC)

Détail du produit anti-UBE2O anticorps

Épitope: AA 1073-1292

Fonction: UBE2O Rabbit pAb

Séquence: LVNEPYYNEA GFDSDRGLQE GYENSRCYNE MALIRVVQSM TQLVRRPPEV FEQEIRQHFS TGGWRLVNRI ESWLETHALL EKAQALPNGV PKASSSPEPP AVAELSDSGQ QEPEDGGPAP GEASQGSDSE GGAQGLASAS RDHTDQTSET APDASVPPSV KPKKRRKSYR SFLPEKSGYP DIGFPLFPLS KGFIKSIRGV LTQFRAALLE AGMPECTEDK

Réactivité croisée: Humain

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1073-1292 of human UBE2O (NP_071349.3).

Isotype: IgG

Information d'application

Indications d'application: IHC,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur UBE2O

Antigène: UBE2O (Ubiquitin-Conjugating Enzyme E2O (UBE2O))

Autre désignation: UBE2O

Sujet: E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins. Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity. Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis. Mediates monoubiquitination at different sites of the nuclear localization signal (NLS of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location. Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly.,UBE2O,E2-230K,Cell Biology & Developmental Biology,Ubiquitin,Ubiquitin-Proteasome Signaling Pathway,UBE2O

Poids moléculaire: 141kDa

ID gène: 63893

UniProt: Q9C0C9