UPF3A anticorps (AA 327-476)

N° du produit ABIN7271227

Cet anticorps Lapin Polyclonal détecte spécifiquement UPF3A dans WB et IF. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour UPF3A anticorps (AA 327-476) (ABIN7271227)

Antigène: UPF3A (UPF3 Regulator of Nonsense Transcripts Homolog A (UPF3A))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UPF3A est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-UPF3A anticorps

Épitope: AA 327-476

Fonction: UPF3A Rabbit pAb

Séquence: EGSLEEPQET SHSGSDKEHR DVERSQEQES EAQRYHVDDG RRHRAHHEPE RLSRRSEDEQ RWGKGPGQDR GKKGSQDSGA PGEAMERLGR AQRCDDSPAP RKERLANKDR PALQLYDPGA RFRARECGGN RRICKAEGSG TGPEKREEAE

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 327-476 of human UPF3A (NP_075387.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur UPF3A

Antigène: UPF3A (UPF3 Regulator of Nonsense Transcripts Homolog A (UPF3A))

Autre désignation: UPF3A

Sujet: This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome 13. Two splice variants encoding different isoforms have been found for this gene.,UPF3A,HUPF3A,RENT3A,UPF3,Epigenetics & Nuclear Signaling,Signal Transduction,UPF3A

Poids moléculaire: 17kDa/51kDa/54kDa

ID gène: 65110

UniProt: Q9H1J1