Recombinant SARS-CoV-2 Nucleocapsid anticorps

N° du produit ABIN7271744

L’anticorps anti-SARS-CoV-2 Nucleocapsid Chimeric Souris est utilisé pour la détection de SARS-CoV-2 Nucleocapsid dans des échantillons de SARS Coronavirus-2 (SARS-CoV-2). Il a été validé pour ELISA.

Aperçu rapide pour Recombinant SARS-CoV-2 Nucleocapsid anticorps (ABIN7271744)

Antigène: SARS-CoV-2 Nucleocapsid (SARS-CoV-2 N)

Type d'anticorp: Recombinant Antibody

Reactivité: SARS Coronavirus-2 (SARS-CoV-2)

Hôte: Souris

Clonalité: Chimeric

Conjugué: Cet anticorp SARS-CoV-2 Nucleocapsid est non-conjugé

Application: ELISA

Classe de qualité: MALS verified

Clone: AM223

Détail du produit anti-SARS-CoV-2 Nucleocapsid anticorps

Fonction: Anti-SARS-CoV-2 Nucleocapsid Antibody, Chimeric mAb, Human IgG1 (AM223) (MALS verified)

Specificité: This product can recognize SARS-CoV-2 Nucleocapsid protein. Cross-reactivity with Nucleocapsid protein of other coronaviruses has not been tested.

Attributs du produit: Recombinant Antibodies produced in CHO. Anti-SARS-CoV-2 Nucleocapsid Antibody, Chimeric mAb, Human IgG1 is a chimeric monoclonal antibody recombinantly expressed from CHO cells, which combines the variable region of a mouse monoclonal antibody with human IgG1 constant domain. The mouse monoclonal antibody was obtained from a mouse immunized with recombinant SARS-CoV-2 Nucleocapsid Protein. This chimeric antibody is purified by Protein A affinity chromatography. As verified by binding test with N-NTD and N-CTD protein, this antibody can only bind to N-CTD (AA Ser 255 - Pro 364). ELISA test validated that this antibody can potently recognize the N protein variant with mutation located within CTD. It can also bind multiple N protein variants with similar affinity as compared to the wild type N protein.

Immunogène: Anti-SARS-CoV-2 Nucleocapsid Antibody, Chimeric mAb, Human IgG1 is a chimeric monoclonal antibody recombinantly expressed from CHO cells, which combines the variable region of a mouse monoclonal antibody with human IgG1 constant domain. The mouse monoclonal antibody was obtained from a mouse immunized with recombinant SARS-CoV-2 Nucleocapsid Protein. This chimeric antibody is purified by Protein A affinity chromatography. As verified by binding test with N-NTD ABIN7013108 and ABIN7013321) and N-CTD ABIN6992431 and ABIN7013323) protein, this antibody can only bind to N-CTD (AA Ser 255 - Pro 364). ELISA test validated that this antibody can potently recognize the N protein variant with mutation located within CTD ). It can also bind multiple N protein variants with similar affinity as compared to the wild type N protein ABIN6952454 and ABIN6952460).

Isotype: IgG1

Information d'application

Indications d'application: This antibody can be paired with other Anti-SARS-CoV-2 nucleocapsid antibodies ABIN7271743 and ABIN7273332) to detect SARS-CoV-2 nucleocapsid protein in sandwich ELISA or LFA assay.

Restrictions: For Research Use only

Stockage

Format: Liquid

Stock: -80 °C

Stockage commentaire: -70°C

Détails sur SARS-CoV-2 Nucleocapsid

Antigène: SARS-CoV-2 Nucleocapsid (SARS-CoV-2 N)

Autre désignation: SARS-CoV-2 Nucleocapsid protein

Sujet: Nucleocapsid (N) protein is the most abundant protein found in coronavirus. CoV N protein is a highly immunogenic phosphoprotein important for viral genome replication and modulation of cell signaling pathways. It was first identified by a research team while they were screening for ADP-ribosylated proteins during coronavirus (CoV) infection (Grunewald M. E., et al. 2017, Virology, 517: 62-68). The array of diverse functional activities accommodated in N protein makes it more than a structural protein but also an interesting target in the development of antiviral therapeutics. Because of the conservation of N protein sequence and its strong immunogenicity, N protein of coronavirus is chosen as a diagnostic tool.