L’anticorps anti-EpCAM Monoclonal produit chez le Souris a été validé pour FACS. Il convient pour la détection de EpCAM dans des échantillons provenant de Humain.
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The clone HEA-125 recognizes epithelium-specific surface glycoprotein having ~34 kDa which is currently known as EpCAM (Epithelial Cell Adhesion Molecule) or CD326. This antigen is expressed on most normal epithelial cells and highly expressed gastrointestinal carcinomas. It functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy.