BCR anticorps

N° du produit ABIN7384420

Cet anticorps anti-BCR est un anticorps Monoclonal produit chez le Lapin, détectant BCR dans WB et IHC (p). Convient pour Humain.

Aperçu rapide pour BCR anticorps (ABIN7384420)

Antigène: BCR (Breakpoint Cluster Region (BCR))

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp BCR est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: R02-6I0

Détail du produit anti-BCR anticorps

Purification: Affinity Purified

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-1:2000 IHC 1:50-1:100

Restrictions: For Research Use only

Stockage

Concentration: 300 μg/mL

Buffer: 50 mM Tris-Glycine( pH 7.4), 0.15M NaCl, 40 % Glycerol, 0.01 % Sodium azide and 0.05 % BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur BCR

Antigène: BCR (Breakpoint Cluster Region (BCR))

Autre désignation: Bcr

Sujet: ALL,bcr,BCR1,Breakpoint cluster region,CML,D22S11,D22S662,PHL,Renal carcinoma antigen NY-REN-26,A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.

Poids moléculaire:

Observed_MW: 160kDa

Calculated_MW: 143kDa

ID gène: 613

UniProt: P11274

Pathways: Regulation of Leukocyte Mediated Immunity, Platelet-derived growth Factor Receptor Signaling