C-AMP Protein Kinase (Catalytic Subunit) anticorps

N° du produit ABIN7384424

Cet anticorps Lapin Monoclonal détecte spécifiquement C-AMP Protein Kinase dans WB, IP, IF et IHC (p). Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour C-AMP Protein Kinase (Catalytic Subunit) anticorps (ABIN7384424)

Antigène: C-AMP Protein Kinase

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Inconjugué

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: R07-8H3

Détail du produit

Épitope: Catalytic Subunit

Purification: Affinity Purified

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-1:2000 IHC 1:50-1:100 IF 1:50-1:100

Restrictions: For Research Use only

Stockage

Concentration: 300 μg/mL

Buffer: 50 mM Tris-Glycine( pH 7.4), 0.15M NaCl, 40 % Glycerol, 0.01 % Sodium azide and 0.05 % BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détail du antigène

Antigène: C-AMP Protein Kinase

Autre désignation: cAMP Protein Kinase

Sujet: CAMP dependent protein kinase alpha catalytic subunit,cAMP dependent protein kinase beta catalytic subunit,cAMP dependent protein kinase catalytic beta subunit isoform 4ab,cAMP dependent protein kinase catalytic subunit alpha,cAMP dependent protein kinase catalytic subunit alpha,isoform 1,cAMP dependent protein kinase catalytic subunit beta,cAMP-dependent protein kinase catalytic subunit alpha,KAPCA,PKA C alpha,PKA C beta,PKA C-alpha,PKACA,PKACB,PPNAD4,PRKACA,PRKACAA,PRKACB,Protein kinase A catalytic subunit alpha,Protein kinase A catalytic subunit,Protein kinase A catalytic subunit beta,Protein kinase cAMP dependent catalytic alpha,Protein kinase cAMP dependent catalytic beta,This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms.

Poids moléculaire:

Observed_MW: 41kDa

Calculated_MW: 41kDa

ID gène: 5566

UniProt: P17612