Recombinant MUC16 (Sofituzumab Biosimilar) anticorps

N° du produit ABIN7488033

Cet anticorps anti-MUC16 (Sofituzumab Biosimilar) Monoclonal Mammalian Cells (ABIN7488033) détecte spécifiquement MUC16 (Sofituzumab Biosimilar) dans ELISA. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Recombinant MUC16 (Sofituzumab Biosimilar) anticorps (ABIN7488033)

Antigène: MUC16 (Sofituzumab Biosimilar)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Mammalian Cells

Clonalité: Monoclonal

Conjugué: Cet anticorp MUC16 (Sofituzumab Biosimilar) est non-conjugé

Application: ELISA

Classe de qualité: Research Grade

Détail du produit anti-MUC16 (Sofituzumab Biosimilar) anticorps

Expression System: Mammalian cells

Fonction: Sofituzumab Biosimilar - Anti-MUC16, CA125 mAb

Attributs du produit: Antibody Type: IgG1-kappa

Purification: Recombinant antibody expressed in mammalien cells and purified.

Isotype: IgG1 kappa

Information d'application

Restrictions: For Research Use only

Stockage

Buffer: PBS pH 7.5

Stock: -80 °C

Stockage commentaire: store at -80°C

Détails sur MUC16 (Sofituzumab Biosimilar)

Antigène: MUC16 (Sofituzumab Biosimilar)

Classe de substances: Biosimilar

Sujet: DMUC5754A (conjugate),MMUC1206A (nonconjugate)
Sofituzumab is investigated for the treatment of Platinum-Resistant Ovarian Cancer or Unresectable Pancreatic Cancer. Sofituzumab Vedotin (also known as DMUC5754A and RG-7458) is an antibody-drug conjugate (ADC) that contains the humanized IgG1 anti-MUC16 monoclonal antibody (mAb) and a potent anti-mitotic agent, monomethyl auristatin E (MMAE), linked through a protease-labile linker, maleimidocaproyl-valine-citrulline-p-aminobenzyloxycarbonyl. DMUC5754A binds to the MUC16 extracellular domain with high affinity, and shows potent and selective anti-tumor activity in MUC16-expressing human ovarian cancer (OC) and pancreatic cancer (PC) mouse xenograft models. The targeted therapeutic strategy of DMUC5754A resulted in enhanced tumor-specific activity of MMAE, while minimizing exposure to tissues that do not express MUC16.

Numéro CAS: 1418200-58-4