BRCC3 anticorps (AA 266-316)

N° du produit ABIN7448440

Cet anticorps Lapin Polyclonal détecte spécifiquement BRCC3 dans IHC. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour BRCC3 anticorps (AA 266-316) (ABIN7448440)

Antigène: BRCC3 (BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BRCC3 est non-conjugé

Application: Immunohistochemistry (IHC)

Détail du produit anti-BRCC3 anticorps

Épitope: AA 266-316

Fonction: Rabbit anti-BRCC36 IHC Antibody, Affinity Purified

Homologie: Mouse,Horse,Pig,Panda,Orangutan,Monkey,White-tufted-ear marmoset,Dusky titi monkey,Nine-banded armadillo,Crab-eating macaque,Little brown bat,African elephant,Northern white-cheeked gibbon,Greater horseshoe bat

Purification: Affinity Purified

Immunogène: Between AA 266 and 316

Isotype: IgG

Information d'application

Indications d'application: 1:100 - 1:500

Restrictions: For Research Use only

Stockage

Concentration: 250 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur BRCC3

Antigène: BRCC3 (BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3))

Autre désignation: BRCC36

Sujet: Background: BRCA1/BRCA2-containing complex subunit 36 (BRCC36) is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. BRCC36 is a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites and leads to targeting of the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, BRCC36 specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs) [taken from the Universal Protein Resource (UniProt) P46736].

ID gène: 79184

NCBI Accession: NP_077308

UniProt: P46736

Pathways: Positive Regulation of Response to DNA Damage Stimulus