CSN3 anticorps (AA 325-375)

N° du produit ABIN7448493

Cet anticorps anti-CSN3 est un anticorps Lapin Polyclonal détectant CSN3 dans IHC. Adapté pour Humain.

Aperçu rapide pour CSN3 anticorps (AA 325-375) (ABIN7448493)

Antigène: CSN3 (Casein kappa (CSN3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CSN3 est non-conjugé

Application: Immunohistochemistry (IHC)

Détail du produit anti-CSN3 anticorps

Épitope: AA 325-375

Fonction: Rabbit anti-CSN3 IHC Antibody, Affinity Purified

Homologie: Mouse,Rat,X. tropicalis,Chicken,Turkey,Bovine,Dog,Horse,Guinea pig_10141,Panda,Orangutan,Monkey,Chimpanzee,White-tufted-ear marmoset,Crab-eating macaque,Tasmanian devil,African elephant,Green anole,Small-eared galago,Gray short-tailed opossum,Naked mole rat,Chinese hamster,Thirteen-lined ground squirrel,Duckbill platypus,West Indian ocean coelacanth,Little brown bat,Zebra finch,Northern white-cheeked gibbon

Purification: Affinity Purified

Immunogène: Between AA 325 and 375

Isotype: IgG

Information d'application

Indications d'application: 1:100 - 1:500

Restrictions: For Research Use only

Stockage

Concentration: 250 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur CSN3

Antigène: CSN3 (Casein kappa (CSN3))

Autre désignation: CSN3

Sujet: Background: CSN3 is one of eight subunits (CSN1 to 8) of the highly conserved COP9 signalsome (CSN) complex originally identified as a regulator of light-mediated development in Arabidopsis. Characterization of CSN from yeast to mammals reveals its function as a modulator of signal transduction pathways involved in a variety of cellular and developmental processes. One of the major functions of the CSN is the regulation of protein degradation via intersection with the ubiquitin-proteasome pathway and regulation of E3-ubiquitin ligases. The CSN also possesses kinase activity. CSN3 is the kinase associated with the CSN complex that phosphorylates signal transducers such as I-kappa-Balpha, p105, and c-Jun. Human CSN3 maps to the Smith-Magenis syndrome locus. Microdeletions in this locus results in mental retardation, skeletal abnormalities, sleep disorder, and neurobehavior anomalies.

ID gène: 8533

NCBI Accession: NP_003644

UniProt: Q9UNS2