MTA3 anticorps (AA 400-450)

N° du produit ABIN7448677

Cet anticorps Lapin Polyclonal détecte spécifiquement MTA3 dans IHC. Il présente une réactivité envers Humain.

Aperçu rapide pour MTA3 anticorps (AA 400-450) (ABIN7448677)

Antigène: MTA3 (Metastasis Associated 1 Family, Member 3 (MTA3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MTA3 est non-conjugé

Application: Immunohistochemistry (IHC)

Détail du produit anti-MTA3 anticorps

Épitope: AA 400-450

Fonction: Rabbit anti-MTA3 IHC Antibody, Affinity Purified

Homologie: Orangutan,Monkey,Chimpanzee,White-tufted-ear marmoset,Crab-eating macaque,Northern white-cheeked gibbon,Small-eared galago

Purification: Affinity Purified

Immunogène: Between AA 400 and 450

Isotype: IgG

Information d'application

Indications d'application: 1:100 - 1:500

Restrictions: For Research Use only

Stockage

Concentration: 250 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur MTA3

Antigène: MTA3 (Metastasis Associated 1 Family, Member 3 (MTA3))

Autre désignation: MTA3

Sujet: Background: MTA3 (metastasis-associated protein 3) is a component of the NuRD (nucleosome remodeling and histone deacetylation) complex. MTA3 is a member of a family of proteins (MTA1-3) differentially expressed in metastatic breast cancer cells. MTA3 functions as a repressor of the transcription factor Snail, a factor involved in epithelial to mesenchymal transitions. MTA3 expression is estrogen dependent in breast cancer cells. Studies show that ERalpha selectively bind the MTA3 promoter in an SP1-dependent fashion to stimulate MTA3 gene transcription.

ID gène: 57504

NCBI Accession: NP_001317371

UniProt: Q9BTC8

Pathways: Chromatin Binding