PUS1 anticorps (AA 377-427)

N° du produit ABIN7448747

L’anticorps Lapin Polyclonal anti-PUS1 a été validé pour IHC. Il convient pour détecter PUS1 dans des échantillons de Humain.

Aperçu rapide pour PUS1 anticorps (AA 377-427) (ABIN7448747)

Antigène: PUS1 (Pseudouridylate Synthase 1 (PUS1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PUS1 est non-conjugé

Application: Immunohistochemistry (IHC)

Détail du produit anti-PUS1 anticorps

Épitope: AA 377-427

Fonction: Rabbit anti-PUS1 IHC Antibody, Affinity Purified

Homologie: Orangutan,Gorilla,Chimpanzee,White-tufted-ear marmoset,Northern white-cheeked gibbon

Purification: Affinity Purified

Immunogène: Between AA 377 and 427

Isotype: IgG

Information d'application

Indications d'application: 1:100 - 1:500

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur PUS1

Antigène: PUS1 (Pseudouridylate Synthase 1 (PUS1))

Autre désignation: PUS1

Sujet: Background: Pus1 (pseudouridylate synthase 1) is an enzyme that converts uridine to pseudouridine in non-coding RNA substrates. Pus1 modifies uridines at specific positions in a subset of tRNAs. Pseudouridylation is known to affect the structure of tRNAs and stabilize base-stacking and base-pairing in the anticodon loop. Pus1 activity is important for proper folding and function of tRNAs. Pus1 has also been shown to pseudouridylate SRA (steroid receptor RNA activator) and function as a coactivator. Defects in pseudouridylation are associated with the human disease, MLASA (myopathy with lactic acidosis and sideroblastic anemia), an autosomal recessive oxidative phosphorylataion disorder specific to skeletal muscle and bone marrow.

ID gène: 80324

NCBI Accession: NP_079491

UniProt: Q9Y606