MAML2 anticorps (C-Term)

N° du produit ABIN7448985

Cet anticorps anti-MAML2 est un anticorps Lapin Polyclonal détectant MAML2 dans IHC et IF (p). Adapté pour Humain.

Aperçu rapide pour MAML2 anticorps (C-Term) (ABIN7448985)

Antigène: MAML2 (Mastermind-Like 2 (MAML2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAML2 est non-conjugé

Application: Immunohistochemistry (IHC), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-MAML2 anticorps

Épitope: C-Term

Fonction: Rabbit anti-MAML2 IHC Antibody, Affinity Purified

Homologie: Mouse,Bovine,Dog,Horse,Rabbit,Guinea pig_10141,Panda,Orangutan,Monkey,Gorilla,Chimpanzee,Naked mole rat,Small-eared galago,Little brown bat,African elephant,Crab-eating macaque,White-tufted-ear marmoset,Ferret

Purification: Affinity Purified

Immunogène: Between AA 1100 and C-term

Isotype: IgG

Information d'application

Indications d'application:

IHC-IF: 1:50 - 1:500

IHC: 1:100 - 1:500

Restrictions: For Research Use only

Stockage

Concentration: 250 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur MAML2

Antigène: MAML2 (Mastermind-Like 2 (MAML2))

Autre désignation: MAML2

Sujet: Background: There are 3 MAML (mastermind-like) proteins in mammals (MAML1-3). MAML2 is a critical coactivator for NOTCH signaling. MAML2 associates with NOTCH and CSL in a ternary complex and functions to activate transcription of HES and hairy-related basic helix-loop-helix transcription factors. MAML2 has been identified in a chromosomal rearrangement and fusion with MECT1 in mucoepidermoid carcinomas, secondary acute myeloid leukemia, hidradenomas, and myelodysplastic syndrome. MECT1 is a CREB regulator, and when fused with the transactivational domain of MAML2, imparts constitutive activation of CREB-dependent transcription that may promote oncogenesis.

ID gène: 84441

UniProt: Q8IZL2