CD45RO anticorps

N° du produit ABIN7449553

Cet anticorps Souris Monoclonal détecte spécifiquement CD45RO dans IHC, WB, IF (p), ICC et mIF. Il présente une réactivité envers Humain.

Aperçu rapide pour CD45RO anticorps (ABIN7449553)

Antigène: CD45RO

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD45RO est non-conjugé

Application: Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Multiplex Immunofluorescence (mIF)

Clone: UCHL-1

Détail du produit anti-CD45RO anticorps

Fonction: Mouse anti-CD45RO Monoclonal Antibody, Purified [UCHL-1]

Immunogène: Cultured T-cells from an IL-2-dependent T-cell line (CA1)

Isotype: IgG

Information d'application

Indications d'application:

IHC-IF: 1:100 to 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IHC: 1:100 - 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

ICC: 1:100 - 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections.

WB: 05:10:00

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: Phosphate Buffered Saline (PBS) pH 8.2 with 0.1 % BSA and 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur CD45RO

Antigène: CD45RO

Autre désignation: CD45RO

Sujet: Background: CD45RO is also known as protein tyrosine phosphatase receptor type C (PTPRC). It is a protein tyrosine phosphatase required for T-cell activation through the antigen receptor. CD45RO acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, CD45RO recruits and dephosphorylates SKAP1 and FYN. It also dephosphorylates LYN, and thereby modulates LYN activity (By similarity)[taken from UniProtKB (Entry: P08575)].

ID gène: 5788

NCBI Accession: NP_002829

UniProt: P08575