Importin 11 anticorps (AA 925-975)

N° du produit ABIN7450360

Cet anticorps Lapin Polyclonal détecte spécifiquement Importin 11 dans WB et IP. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour Importin 11 anticorps (AA 925-975) (ABIN7450360)

Antigène: Importin 11 (IPO11)

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Importin 11 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Détail du produit anti-Importin 11 anticorps

Épitope: AA 925-975

Fonction: Rabbit anti-Importin 11/IPO11 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: Between AA 925 and 975

Isotype: IgG

Information d'application

Indications d'application:

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur Importin 11

Antigène: Importin 11 (IPO11)

Autre désignation: Importin 11/IPO11

Sujet: Background: Importin 11 functions in nuclear protein import as nuclear transport receptor. It serves as receptor for nuclear localization signals (NLS) in cargo substrates, and is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Importin 11/IPO11 mediates the nuclear import of UBE2E3, and of RPL12 (By similarity) [taken from the Universal Protein Resource (UniProt) Q9UI26].

ID gène: 51194

UniProt: Q9UI26

Pathways: Protein targeting to Nucleus