FERMT2 anticorps (AA 175-225)

N° du produit ABIN7450396

Cet anticorps Lapin Polyclonal détecte spécifiquement FERMT2 dans WB et IP. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour FERMT2 anticorps (AA 175-225) (ABIN7450396)

Antigène: FERMT2 (Fermitin Family Member 2 (FERMT2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FERMT2 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Détail du produit anti-FERMT2 anticorps

Épitope: AA 175-225

Fonction: Rabbit anti-Kindlin-2 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: Between AA 175 and 225

Isotype: IgG

Information d'application

Indications d'application:

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur FERMT2

Antigène: FERMT2 (Fermitin Family Member 2 (FERMT2))

Autre désignation: Kindlin-2

Sujet: Background: Kindlin-2 is a scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. It binds to membranes enriched in phosphoinositides. It also enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading, this requires both its ability to interact with integrins and with phospholipid membranes. Kindlin-2 is required for the assembly of focal adhesions and participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Kindlin-2 recruits FBLIM1 to focal adhesions. It plays a role in the TGFB1 and integrin signaling pathways, and it stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling [taken from the Universal Protein Resource (UniProt) Q96AC1].

ID gène: 10979

NCBI Accession: NP_006823

UniProt: Q96AC1

Pathways: Cell-Cell Junction Organization