PAN2 anticorps (AA 1-50)

N° du produit ABIN7450538

L’anticorps anti-PAN2 Polyclonal Lapin est utilisé pour la détection de PAN2 dans des échantillons de Humain et Souris. Il a été validé pour WB et IP.

Aperçu rapide pour PAN2 anticorps (AA 1-50) (ABIN7450538)

Antigène: PAN2 (PAN2 Poly(A) Specific Ribonuclease Subunit Homolog (PAN2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PAN2 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Détail du produit anti-PAN2 anticorps

Épitope: AA 1-50

Fonction: Rabbit anti-PAN2/USP52 Antibody, Affinity Purified

Homologie: Rat

Purification: Affinity Purified

Immunogène: Between AA 1 and 50

Isotype: IgG

Information d'application

Indications d'application:

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur PAN2

Antigène: PAN2 (PAN2 Poly(A) Specific Ribonuclease Subunit Homolog (PAN2))

Autre désignation: PAN2/USP52

Sujet: Background: PAB-dependent poly(A)-specific ribonuclease subunit PAN2 is the catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1 [taken from the Universal Protein Resource (UniProt) Q504Q3].

ID gène: 9924

UniProt: Q504Q3