MAML2 anticorps (AA 250-300)

N° du produit ABIN7451271

Cet anticorps anti-MAML2 est un anticorps Lapin Polyclonal détectant MAML2 dans IP. Adapté pour Humain.

Aperçu rapide pour MAML2 anticorps (AA 250-300) (ABIN7451271)

Antigène: MAML2 (Mastermind-Like 2 (MAML2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAML2 est non-conjugé

Application: Immunoprecipitation (IP)

Détail du produit anti-MAML2 anticorps

Épitope: AA 250-300

Fonction: Rabbit anti-MAML2 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: between AA 250 and 300

Isotype: IgG

Information d'application

Indications d'application:

IP: 2 - 10 μg/mg lysate

WB: Not recommended. Use rabbit anti-MAML2 antibody A300-682A.

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur MAML2

Antigène: MAML2 (Mastermind-Like 2 (MAML2))

Autre désignation: MAML2

Sujet: Background: There are 3 MAML (mastermind-like) proteins in mammals (MAML1-3). MAML2 is a critical coactivator for NOTCH signaling. MAML2 associates with NOTCH and CSL in a ternary complex and functions to activate transcription of HES and hairy-related basic helix-loop-helix transcription factors. MAML2 has been identified in a chromosomal rearrangement and fusion with MECT1 in mucoepidermoid carcinomas, secondary acute myeloid leukemia, hidradenomas, and myelodysplastic syndrome. MECT1 is a CREB regulator, and when fused with the transactivational domain of MAML2, imparts constitutive activation of CREB-dependent transcription that may promote oncogenesis.

ID gène: 84441

UniProt: Q8IZL2