CIZ1 anticorps (AA 325-375)

N° du produit ABIN7451704

Cet anticorps Lapin Polyclonal détecte spécifiquement CIZ1 dans WB et IP. Il présente une réactivité envers Humain.

Aperçu rapide pour CIZ1 anticorps (AA 325-375) (ABIN7451704)

Antigène: CIZ1 (CDKN1A Interacting Zinc Finger Protein 1 (CIZ1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CIZ1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Détail du produit anti-CIZ1 anticorps

Épitope: AA 325-375

Fonction: Rabbit anti-CIZ1 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: between AA 325 and 375

Isotype: IgG

Information d'application

Indications d'application:

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur CIZ1

Antigène: CIZ1 (CDKN1A Interacting Zinc Finger Protein 1 (CIZ1))

Autre désignation: CIZ1

Sujet: Background: CIZ1 (Cip1 interacting zinc-finger protein) was identified as a protein that associates with the cell-cycle inhibiting protein, p21 (Cip1/Waf1). CIZ1 is a member of the matrin 3 protein family and has been shown to bind DNA consensus sequences and co-localize with PCNA during replication. In breast cancer cells, CIZ1 was shown to associate with Cdk2 and dynein light chain 1 (DLC1), a cytoskeletal signaling protein involved in cell cycle regulation and tumorigenesis. Studies of the role of CIZ1 in breast tumorigenesis revealed that CIZ1 is an estrogen-responsive gene that functions as a coactivator of the estrogen receptor. Targeted depletion of CIZ1 inhibits entry into S-phase. This finding along with evidence that CIZ1 interacts with multiple cell cycle regulatory proteins and localizes to DNA replication foci, indicates that CIZ1 plays a critical role in the regulation of DNA replication.

ID gène: 25792

NCBI Accession: NP_036259

UniProt: Q9ULV3

Pathways: Maintenance of Protein Location