TNKS1BP1 anticorps (AA 350-400)

N° du produit ABIN7452083

L’anticorps Lapin Polyclonal anti-TNKS1BP1 a été validé pour WB et IP. Il convient pour détecter TNKS1BP1 dans des échantillons de Humain.

Aperçu rapide pour TNKS1BP1 anticorps (AA 350-400) (ABIN7452083)

Antigène: TNKS1BP1 (Tankyrase 1 Binding Protein 1, 182kDa (TNKS1BP1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TNKS1BP1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Détail du produit anti-TNKS1BP1 anticorps

Épitope: AA 350-400

Fonction: Rabbit anti-TAB182 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: between AA 350 and 400

Isotype: IgG

Information d'application

Indications d'application:

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur TNKS1BP1

Antigène: TNKS1BP1 (Tankyrase 1 Binding Protein 1, 182kDa (TNKS1BP1))

Autre désignation: TAB182

Sujet: Background: TAB182 (tankyrase 1-binding protein of 182 kDa) was identified in a two-hybrid screen in search of tankyrase 1-interacting proteins. Tankyrase 1 is a poly (ADP-ribose) polymerase (PARP) that ribosylates the negative regulator of telomere length, TRF1 (telomere-repeat binding factor). Ribosylation of TRF1 has been shown to result in the inhibition of TRF1 binding and an induction of telomere elongation. TAB182 and TRF1 bind multiple discrete and overlapping sites of the tankyrase 1 ankyrin domain. This finding suggests that TAB182 may act as a scaffold to mediate higher order protein complex formation at telomeres. TAB182 has also been suggested to serve a role in the cytoplasm as it has been found to localize to the cytoplasmic cortical actin network.

ID gène: 85456

NCBI Accession: NP_203754

UniProt: Q9C0C2