TNKS1BP1 anticorps (AA 350-400)

N° du produit ABIN7452083

Détail du produit anti-TNKS1BP1 anticorps

Antigène: TNKS1BP1 (Tankyrase 1 Binding Protein 1, 182kDa (TNKS1BP1))

Épitope: AA 350-400

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TNKS1BP1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Fonction: Rabbit anti-TAB182 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: between AA 350 and 400

Isotype: IgG

Information d'application

Indications d'application:

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur TNKS1BP1

Antigène: TNKS1BP1 (Tankyrase 1 Binding Protein 1, 182kDa (TNKS1BP1))

Autre désignation: TAB182 (TNKS1BP1 Produits)

Synonymes: anticorps TAB182, anticorps Tab182, anticorps mKIAA1741, anticorps tankyrase 1 binding protein 1, anticorps 182 kDa tankyrase-1-binding protein, anticorps TNKS1BP1, anticorps LOC100625088, anticorps Tnks1bp1

Sujet: Background: TAB182 (tankyrase 1-binding protein of 182 kDa) was identified in a two-hybrid screen in search of tankyrase 1-interacting proteins. Tankyrase 1 is a poly (ADP-ribose) polymerase (PARP) that ribosylates the negative regulator of telomere length, TRF1 (telomere-repeat binding factor). Ribosylation of TRF1 has been shown to result in the inhibition of TRF1 binding and an induction of telomere elongation. TAB182 and TRF1 bind multiple discrete and overlapping sites of the tankyrase 1 ankyrin domain. This finding suggests that TAB182 may act as a scaffold to mediate higher order protein complex formation at telomeres. TAB182 has also been suggested to serve a role in the cytoplasm as it has been found to localize to the cytoplasmic cortical actin network.

ID gène: 85456

NCBI Accession: NP_203754

UniProt: Q9C0C2