BRISC and BRCA1 A Complex Member 1 (BABAM1) (AA 1-50) anticorps

N° du produit ABIN7452241

Cet anticorps Lapin Polyclonal détecte spécifiquement dans IP. Il présente une réactivité envers Humain.

Aperçu rapide pour BRISC and BRCA1 A Complex Member 1 (BABAM1) (AA 1-50) anticorps (ABIN7452241)

Antigène: BRISC and BRCA1 A Complex Member 1 (BABAM1)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Immunoprecipitation (IP)

Détail du produit

Épitope: AA 1-50

Fonction: Rabbit anti-MERIT40 Antibody, Affinity Purified

Homologie: Orangutan

Purification: Affinity Purified

Immunogène: between AA 1 and 50

Isotype: IgG

Information d'application

Indications d'application:

IP: 2 - 5 μg/mg lysate

WB: Not recommended. ABIN7452241 has not performed satisfactorily when used for WB of MERIT40 in crude preparations (e.g. whole cell lysate). This antibody can be used for WB of enriched (e.g. immunoprecipitated) sources of MERIT40.

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détail du antigène

Antigène: BRISC and BRCA1 A Complex Member 1 (BABAM1)

Autre désignation: MERIT40

Sujet: Background: MERIT40 (mediator of RAP80 interactions and targeting subunit of 40 kDa) is a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites and leads to targeting of the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. MERIT40 probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin [taken from the Universal Protein Resource (UniProt) Q9NWV8].

ID gène: 29086

NCBI Accession: NP_054892

UniProt: Q9NWV8

Pathways: Positive Regulation of Response to DNA Damage Stimulus