Recombinant TIM3 anticorps (AA 231-281)

N° du produit ABIN7452586

Cet anticorps Lapin Monoclonal détecte spécifiquement TIM3 dans WB et IP. Il présente une réactivité envers Souris.

Aperçu rapide pour Recombinant TIM3 anticorps (AA 231-281) (ABIN7452586)

Antigène: TIM3 (TIM 3) (Hepatitis A Virus Cellular Receptor 2 (TIM 3))

Type d'anticorp: Recombinant Antibody

Reactivité: Souris

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp TIM3 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Clone: BLR207K

Détail du produit anti-TIM3 anticorps

Épitope: AA 231-281

Fonction: Rabbit anti-TIM3 Recombinant Monoclonal Antibody [BLR207K]

Immunogène: between AA 231 and 281 (C-term)

Isotype: IgG

Information d'application

Indications d'application:

IP: 20 μL/1 mg lysate

WB: 01:01,00

Restrictions: For Research Use only

Stockage

Concentration: 100 μg/mL

Buffer: Borate Buffered Saline (BBS) pH 8.2 with 0.1 % BSA and 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur TIM3

Antigène: TIM3 (TIM 3) (Hepatitis A Virus Cellular Receptor 2 (TIM 3))

Autre désignation: TIM3

Classe de substances: Virus

Sujet: Background: TIM3 (HAVCR2) is a cell surface receptor implicated in modulating innate and adaptive immune responses. It is generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. TIM3 regulates macrophage activation, inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses, and promotes immunological tolerance. In CD8+ cells TIM3 attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion.  [taken from the Universal Protein Resource (UniProt) Q8TDQ0].

ID gène: 171285

NCBI Accession: NP_599011

UniProt: Q8VIM0

Pathways: Regulation of Lipid Metabolism by PPARalpha, Cancer Immune Checkpoints