NOC2L anticorps (AA 699-749)

N° du produit ABIN7453539

Cet anticorps anti-NOC2L est un anticorps Lapin Polyclonal détectant NOC2L dans WB et IHC (fp). Adapté pour Humain.

Aperçu rapide pour NOC2L anticorps (AA 699-749) (ABIN7453539)

Antigène: NOC2L (Nucleolar Complex Associated 2 Homolog (NOC2L))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NOC2L est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Détail du produit anti-NOC2L anticorps

Épitope: AA 699-749

Fonction: Rabbit anti-NIR Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: Between AA 699 and 749

Isotype: IgG

Information d'application

Indications d'application:

IHC: 1:1,000 - 1:5,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: Not recommended

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur NOC2L

Antigène: NOC2L (Nucleolar Complex Associated 2 Homolog (NOC2L))

Autre désignation: NIR

Sujet: Background: Novel INHAT repressor (NIR) acts as an inhibitor of histone acetyltransferase activity, it prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. NIR acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. It is involved in the regulation of p53/TP53-dependent apoptosis and it associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter [taken from the Universal Protein Resource (UniProt) Q9Y3T9].

ID gène: 26155

NCBI Accession: NP_056473

UniProt: Q9Y3T9

Pathways: Negative Regulation of intrinsic apoptotic Signaling