SYK anticorps (AA 250-300)

N° du produit ABIN7454368

L’anticorps Lapin Polyclonal anti-SYK a été validé pour IP et IHC (fp). Il convient pour détecter SYK dans des échantillons de Humain.

Aperçu rapide pour SYK anticorps (AA 250-300) (ABIN7454368)

Antigène: SYK (Spleen tyrosine Kinase (SYK))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SYK est non-conjugé

Application: Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Détail du produit anti-SYK anticorps

Épitope: AA 250-300

Fonction: Rabbit anti-SYK Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: between AA 250 and 300

Isotype: IgG

Information d'application

Indications d'application:

IHC: 1:500 - 1:2,000. Epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE tissue sections.

IP: 1 - 4 μg/mg lysate

WB: Not recommended. Use rabbit anti-SYK antibody A300-559A.

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur SYK

Antigène: SYK (Spleen tyrosine Kinase (SYK))

Autre désignation: SYK

Sujet: Background: SYK (spleen tyrosine kinase) is a ubiquitously expressed tyrosine kinase that functions in mediating B and T-cell receptor signaling and is also important to various aspects of leukocyte function that involve cytoskeleton remodeling. In mediating hematopoietic cell signaling, SYK is a substrate of src family kinase activity and is a key-regulator of Akt kinase activity. SYK has also been found to be highly expressed in the mammary gland and has been shown to inhibit tumor growth and metastasis. Invasive breast tumor cell lines have been shown to exhibit reduced or absent levels of SYK, further implicating a role in tumorigenesis and metastasis.

ID gène: 6850

NCBI Accession: NP_003168

UniProt: P43405

Pathways: Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Thromboxane A2 Receptor Signaling, BCR Signaling