PRCC anticorps (AA 125-175)

N° du produit ABIN7454446

Détail du produit anti-PRCC anticorps

Antigène: PRCC (Papillary Renal Cell Carcinoma (Translocation-Associated) (PRCC))

Épitope: AA 125-175

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PRCC est non-conjugé

Application: Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Fonction: Rabbit anti-PRCC Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: between AA 125 and 175

Isotype: IgG

Information d'application

Indications d'application:

IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 5 μg/mg lysate

WB: Not recommended. Use rabbit anti-PRCC antibody A302-340A.

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur PRCC

Antigène: PRCC (Papillary Renal Cell Carcinoma (Translocation-Associated) (PRCC))

Autre désignation: PRCC (PRCC Produits)

Synonymes: anticorps tprc, anticorps XPrcc, anticorps rccp1, anticorps RCCP1, anticorps TPRC, anticorps papillary renal cell carcinoma (translocation-associated), anticorps PRCC, anticorps prcc, anticorps Prcc

Sujet: Background: In a subset of papillary renal cell carcinomas, a t(X,1)(p11,q21) chromosome translocation has been repeatedly reported and is thought to be the cause of the cancer. As a result of the translocation, the transcription factor TFE3 on the X chromosome becomes fused to the PRCC (papillary renal cell carcinoma translocation-associated) gene on chromosome 1. The fused gene results in the fusion of N-terminal proline-rich region of the protein encoded by this gene to the entire TFE3 protein. This protein has been shown to interact with the mitotic checkpoint protein MAD2B, which suggests that the dominant-negative effect of the fusion protein with TFE3 may lead to a mitotic checkpoint defect [taken from NCBI GeneID:5546].

ID gène: 5546

NCBI Accession: NP_005964

UniProt: Q92733