BRISC and BRCA1 A Complex Member 1 (BABAM1) (AA 175-225) anticorps

N° du produit ABIN7454455

L’anticorps Lapin Polyclonal anti- a été validé pour IP et IHC (fp). Il convient pour détecter dans des échantillons de Humain.

Aperçu rapide pour BRISC and BRCA1 A Complex Member 1 (BABAM1) (AA 175-225) anticorps (ABIN7454455)

Antigène: BRISC and BRCA1 A Complex Member 1 (BABAM1)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Détail du produit

Épitope: AA 175-225

Fonction: Rabbit anti-MERIT40 Antibody, Affinity Purified

Homologie: Mouse,Rat,Bovine,Orangutan

Purification: Affinity Purified

Immunogène: between AA 175 and 225

Isotype: IgG

Information d'application

Indications d'application:

IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 10 μg/mg lysate

WB: Not recommended

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détail du antigène

Antigène: BRISC and BRCA1 A Complex Member 1 (BABAM1)

Autre désignation: MERIT40

Sujet: Background: MERIT40 (mediator of RAP80 interactions and targeting subunit of 40 kDa) is a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites and leads to targeting of the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. MERIT40 probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin [taken from the Universal Protein Resource (UniProt) Q9NWV8].

ID gène: 29086

NCBI Accession: NP_054892

UniProt: Q9NWV8

Pathways: Positive Regulation of Response to DNA Damage Stimulus