WWOX anticorps (AA 364-414)

N° du produit ABIN7454501

Cet anticorps anti-WWOX est un anticorps Lapin Polyclonal détectant WWOX dans IP et IHC (fp). Adapté pour Humain.

Aperçu rapide pour WWOX anticorps (AA 364-414) (ABIN7454501)

Antigène: WWOX (WW Domain Containing Oxidoreductase (WWOX))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp WWOX est non-conjugé

Application: Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Détail du produit anti-WWOX anticorps

Épitope: AA 364-414

Fonction: Rabbit anti-WWOX Antibody, Affinity Purified

Homologie: Orangutan

Purification: Affinity Purified

Immunogène: Between AA 364 and 414

Isotype: IgG

Information d'application

Indications d'application:

IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 10 μg/mg lysate

WB: Not recommended. A304-079A has not performed satisfactorily when used for WB of WWOX in crude preparations (e.g. whole cell lysate). This antibody can be used for WB of enriched (e.g. immunoprecipitated) sources of WWOX.

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur WWOX

Antigène: WWOX (WW Domain Containing Oxidoreductase (WWOX))

Autre désignation: WWOX

Sujet: Background: WW domain-containing oxidoreductase (WWOX) is a putative oxidoreductase, acts as a tumor suppressor, plays a role in apoptosis, and is required for normal bone development (by similarity). WWOX may function synergistically with p53/TP53 to control genotoxic stress-induced cell death. It plays a role in TGFB1 signaling and TGFB1-mediated cell death and may also play a role in tumor necrosis factor (TNF)-mediated cell death. WWOX inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm [taken from the Universal Protein Resource (UniProt) Q9NZC7].

ID gène: 51741

UniProt: Q9NZC7