XPO5 anticorps (AA 1154-1204)

N° du produit ABIN7454998

L’anticorps Lapin Polyclonal anti-XPO5 a été validé pour WB, IP et IHC (fp). Il convient pour détecter XPO5 dans des échantillons de Humain et Souris.

Aperçu rapide pour XPO5 anticorps (AA 1154-1204) (ABIN7454998)

Antigène: XPO5 (Exportin 5 (XPO5))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp XPO5 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Détail du produit anti-XPO5 anticorps

Épitope: AA 1154-1204

Fonction: Rabbit anti-Exportin-5 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: Between AA 1154 and 1204

Isotype: IgG

Information d'application

Indications d'application:

IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur XPO5

Antigène: XPO5 (Exportin 5 (XPO5))

Autre désignation: Exportin-5

Sujet: Background: Exportin-5 mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). Exportin-5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. Exportin-5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport [taken from the Universal Protein Resource (UniProt) Q9HAV4].

ID gène: 57510

NCBI Accession: NP_065801

UniProt: Q9HAV4

Pathways: Regulatory RNA Pathways, Protein targeting to Nucleus