BTLA anticorps (APC)

N° du produit ABIN7456383

Cet anticorps Rat Monoclonal détecte spécifiquement BTLA dans FACS. Il présente une réactivité envers Souris.

Aperçu rapide pour BTLA anticorps (APC) (ABIN7456383)

Antigène: BTLA (B and T Lymphocyte Associated (BTLA))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp BTLA est conjugé à/à la APC

Application: Flow Cytometry (FACS)

Clone: PK18-6

Détail du produit anti-BTLA anticorps (APC)

Isotype: IgG1, kappa

Information d'application

Indications d'application: Check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/10^6 cells in 100 μL volume].

Commentaires:

Matching Isotype Control: APC Rat IgG1, κ Isotype Control (ABIN7469823)

Restrictions: For Research Use only

Stockage

Concentration: 0.2 mg/mL

Buffer: PBS with 0.05 % Proclin300, 1 % BSA

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.

Détails sur BTLA

Antigène: BTLA (B and T Lymphocyte Associated (BTLA))

Autre désignation: CD272

Sujet: B- and T-lymphocyte attenuator,Btla,B- and T-lymphocyte-associated protein,CD272,Btla,CD272, also known as B and T lymphocyte attenuator (BTLA), is an Ig superfamily co-inhitory receptor with structural similarity to programmed cell death 1 (PD-1) and CTLA-4. BTLA is expressed on B cells, T cells, macrophages, dendritic cells, NKT cells, and NK cells. Engagement of BTLA by its ligand herpes virus entry mediator (HVEM) is critical for negatively regulating immune response. The absence of BTLA with HVEM inhibitory interactions leads to increased experimental autoimmune encephalomyelitis severity, enhanced rejection of partially mismatched allografts, an increased CD8+ memory T cell population, increased severity of colitis, and reduced effectiveness of T regulatory cells. BTLA plays an important role in the induction of peripheral tolerance of both CD4+ and CD8+ T cells in vivo. Tolerant T cells have significantly higher expression of BTLA compared with effectors and naive T cells. BTLA may cooperate with CTLA-4 and PD-1 to control T cell tolerance and autoimmunity. It was reported that BTLA may regulate T cell function by binding to B7-H4, but further studies are needed to confirm. The existence of three distinct BTLA alleles has been reported.

ID gène: 208154

UniProt: Q7TSA3

Pathways: Cancer Immune Checkpoints