CCR6 anticorps (PE-Cy7)

N° du produit ABIN7457594

Cet anticorps anti-CCR6 est un anticorps Souris Monoclonal détectant CCR6 dans FACS. Adapté pour Humain.

Aperçu rapide pour CCR6 anticorps (PE-Cy7) (ABIN7457594)

Antigène: CCR6 (Chemokine (C-C Motif) Receptor 6 (CCR6))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CCR6 est conjugé à/à la PE-Cy7

Application: Flow Cytometry (FACS)

Clone: G034E3

Détail du produit anti-CCR6 anticorps (PE-Cy7)

Isotype: IgG2b, kappa

Information d'application

Indications d'application: The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.

Commentaires:

Matching Isotype Control: PE/Cyanine7 Mouse IgG2b, κ Isotype Control (ABIN7469798)

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.05 % Proclin300, 1 % BSA

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.

Détails sur CCR6

Antigène: CCR6 (Chemokine (C-C Motif) Receptor 6 (CCR6))

Autre désignation: CD196/CCR6

Sujet: CKRL3, CMKBR6, GPR29, STRL22,GPRCY4,CCR6, also known as CD196/CCR6, is a chemokine receptor that is expressed on immature dendritic cells, B lymphocytes, and memory T cells. CCR6 binds CCL20, although members of the β defensin family also bind CCR6 with a lower affinity. CCR6 positive cells, and its ligand CCL20, have been detected in numerous organs, especially the secondary lymphoid organ. CCL20 is selectively made by the follicle-associated epithelium (FAE) overlying Peyers Patches (PPs) and isolated lymphoid follicles (ILFs). CCL20 contributes to the recruitment of CCR6-expressing B cells to these structures. In humans, CCR6 can function to mediate arrest of T cells on dermal endothelial cells and is highly expressed on T cells resident in both normal and psoriatic skin. CCR6 and/or CCL20 have been implicated in the pathogenesis of rheumatoid arthritis and inflammatory bowel disease. Human T cells that are able to produce IL-17 express CCR6. It suggests that CCL20 and CCR6 have a role in inflammatory diseases by recruiting Th17 cells to target tissues.

ID gène: 1235

UniProt: P51684

Pathways: cAMP Metabolic Process