X-Ray Repair Cross Complementing 5 (C-Term) anticorps

N° du produit ABIN7464656

Détail du produit

Antigène: X-Ray Repair Cross Complementing 5

Épitope: C-Term

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Inconjugué

Application: Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

Réactivité croisée: Humain, Singe

Purification: Protein G purified

Classe de qualité: KO Validated

Immunogène: Recombinant antigen containing the carboxy terminal portion of human Ku80 protein

Clone: 149-8

Isotype: IgG1

Information d'application

Indications d'application: WB: 1:1000-1:10000. ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: Jurkat , Raji , 293T , A431 , HeLa , HepG2 , H1299 , HCT116 , MCF-7 , NT2D1 , PC-3 , U87-MG

Validation: KO/KD, Orthogonal

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, No Preservative

Agent conservateur: Without preservative

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Détail du antigène

Antigène: X-Ray Repair Cross Complementing 5

Synonymes: anticorps KARP-1, anticorps KARP1, anticorps KU80, anticorps KUB2, anticorps Ku86, anticorps NFIV, anticorps AI314015, anticorps Ku80, anticorps X-ray repair cross complementing 5, anticorps X-ray repair complementing defective repair in Chinese hamster cells 5, anticorps XRCC5, anticorps Xrcc5

Sujet: X-ray repair cross complementing 5 , KARP-1 , KARP1 , KU80 , KUB2 , Ku86 , NFIV,The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]

Poids moléculaire: 83 kDa

ID gène: 7520

UniProt: P13010