CXCR2 anticorps (N-Term)

N° du produit ABIN7465307

Cet anticorps anti-CXCR2 est un anticorps Souris Monoclonal détectant CXCR2 dans WB, IF et ICC. Adapté pour Humain.

Aperçu rapide pour CXCR2 anticorps (N-Term) (ABIN7465307)

Antigène: CXCR2 (Chemokine (C-X-C Motif) Receptor 2 (CXCR2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CXCR2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: GT547

Détail du produit anti-CXCR2 anticorps

Épitope: N-Term

Réactivité croisée: Humain

Purification: Affinity purified by Protein A.

Immunogène: Recombinant protein encompassing a sequence within the N-terminus region of human CXCR2. The exact sequence is proprietary.

Isotype: IgG2a

Information d'application

Indications d'application: WB: 1:1000-1:10000. ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: 3xFlag-human CXCR2-transfected 293T

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, No Preservative

Agent conservateur: Without preservative

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Détails sur CXCR2

Antigène: CXCR2 (Chemokine (C-X-C Motif) Receptor 2 (CXCR2))

Autre désignation: C-X-C motif chemokine receptor 2

Sujet: C-X-C motif chemokine receptor 2 , CD182 , CDw128b , CMKAR2 , IL8R2 , IL8RA , IL8RB,The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq]

Poids moléculaire: 41 kDa

ID gène: 3579

UniProt: P25025

Pathways: cAMP Metabolic Process