TRIM72 anticorps

N° du produit ABIN7467171

Détail du produit anti-TRIM72 anticorps

Antigène: TRIM72 (Tripartite Motif Containing 72 (TRIM72))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRIM72 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Humain, Souris

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein encompassing a sequence within the center region of human TRIM72. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Validation: Orthogonal

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.42 mg/mL

Buffer: 1XPBS pH 7, 20 % Glycerol, 0.025 % ProClin 300

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Détails sur TRIM72

Antigène: TRIM72 (Tripartite Motif Containing 72 (TRIM72))

Autre désignation: tripartite motif containing 72 (TRIM72 Produits)

Synonymes: anticorps Trim72, anticorps MG53, anticorps Mg53, anticorps BC067209, anticorps RGD1562778, anticorps tripartite motif containing 72, anticorps tripartite motif containing 72, E3 ubiquitin protein ligase L homeolog, anticorps tripartite motif-containing 72, anticorps TRIM72, anticorps trim72.L, anticorps Trim72

Sujet: Tripartite motif containing 72 , MG53,Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles.

Poids moléculaire: 53 kDa

ID gène: 493829

UniProt: Q6ZMU5