BRISC and BRCA1 A Complex Member 1 (BABAM1) (N-Term) anticorps

N° du produit ABIN7467205

L’anticorps Souris Monoclonal anti- a été validé pour WB, IF et ICC. Il convient pour détecter dans des échantillons de Humain.

Aperçu rapide pour BRISC and BRCA1 A Complex Member 1 (BABAM1) (N-Term) anticorps (ABIN7467205)

Antigène: BRISC and BRCA1 A Complex Member 1 (BABAM1)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Inconjugué

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: GT1251

Détail du produit

Épitope: N-Term

Réactivité croisée: Humain

Purification: Affinity purified by Protein G.

Immunogène: Recombinant protein encompassing a sequence within the N-terminus region of human HSPC142. The exact sequence is proprietary.

Isotype: IgG2a

Information d'application

Indications d'application: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Validation: Overexpression

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, No Preservative

Agent conservateur: Without preservative

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Détail du antigène

Antigène: BRISC and BRCA1 A Complex Member 1 (BABAM1)

Autre désignation: BRISC and BRCA1 A complex member 1

Sujet: BRISC and BRCA1 A complex member 1 , C19orf62 , HSPC142 , MERIT40 , NBA1,Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36. component.

Poids moléculaire: 37 kDa

ID gène: 29086

UniProt: Q9NWV8

Pathways: Positive Regulation of Response to DNA Damage Stimulus