ARID1A anticorps (C-Term)

N° du produit ABIN7467969

Cet anticorps Souris Monoclonal détecte spécifiquement ARID1A dans WB, IF, ICC et IHC (p). Il présente une réactivité envers Humain.

Aperçu rapide pour ARID1A anticorps (C-Term) (ABIN7467969)

Antigène: ARID1A (AT Rich Interactive Domain 1A (SWI-Like) (ARID1A))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ARID1A est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: GT3611

Détail du produit anti-ARID1A anticorps

Épitope: C-Term

Réactivité croisée: Humain, Souris

Purification: Affinity purified by Protein G.

Immunogène: Recombinant protein encompassing a sequence within the C-terminus region of human ARID1A. The exact sequence is proprietary.

Isotype: IgG1

Information d'application

Indications d'application: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: 293T

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 2.61 mg/mL

Buffer: PBS, No Preservative

Agent conservateur: Without preservative

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Détails sur ARID1A

Antigène: ARID1A (AT Rich Interactive Domain 1A (SWI-Like) (ARID1A))

Autre désignation: AT-rich interaction domain 1A

Sujet:

Synonyms: AT-rich interaction domain 1A , B120 , BAF250 , BAF250a , BM029 , C1orf4 , CSS2 , ELD , MRD14 , OSA1 , P270 , SMARCF1 , hELD , hOSA1

Background: This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Poids moléculaire: 242 kDa

ID gène: 8289

UniProt: O14497

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Tube Formation