CCM2 anticorps

N° du produit ABIN7468108

Détail du produit anti-CCM2 anticorps

Antigène: CCM2 (Cerebral Cavernous Malformation 2 (CCM2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CCM2 est non-conjugé

Application: Western Blotting (WB)

Réactivité croisée: Humain

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein encompassing a sequence within the center region of human CCM2. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: 293T

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.4 mg/mL

Buffer: 1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.01 % Thimerosal

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Détails sur CCM2

Antigène: CCM2 (Cerebral Cavernous Malformation 2 (CCM2))

Autre désignation: CCM2 scaffold protein (CCM2 Produits)

Synonymes: anticorps C7orf22, anticorps OSM, anticorps malcavernin, anticorps CCM2, anticorps BC029157, anticorps TUF2, anticorps vtn, anticorps zgc:110233, anticorps CCM2 scaffolding protein, anticorps cerebral cavernous malformation 2, anticorps malcavernin, anticorps CCM2, anticorps Ccm2, anticorps LOC100304744, anticorps ccm2

Sujet:

Synonyms: CCM2 scaffold protein , C7orf22 , OSM , PP10187

Background: This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.

Poids moléculaire: 49 kDa

ID gène: 83605

UniProt: Q9BSQ5

Pathways: Cell-Cell Junction Organization