Recombinant FCAR anticorps

N° du produit ABIN7487710

Cet anticorps anti-FCAR est un anticorps Lapin Chimeric détectant FCAR dans FACS, ELISA et IP. Adapté pour Humain.

Aperçu rapide pour Recombinant FCAR anticorps (ABIN7487710)

Antigène: FCAR (Fc Fragment of IgA, Receptor For (FCAR))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Chimeric

Conjugué: Cet anticorp FCAR est non-conjugé

Application: Flow Cytometry (FACS), ELISA, Immunoprecipitation (IP)

Clone: 14A8

Détail du produit anti-FCAR anticorps

Fonction: Anti-CD89 [14A8 (14.1)], Rabbit IgG, kappa

Specificité: This antibody binds CD89 in the extracellular domain 2, outside the IgA-binding site.

Attributs du produit:

Original Species of Ab: Mouse

Original Format of Ab: IgG1

Purification: Protein A affinity purified

Immunogène: The original antibody was generated by immunizing HCO12 trangene containing mice with recombinant soluble CD89 antigen.

Isotype: IgG kappa

Information d'application

Indications d'application: This antibody binds human CD89 with a dissociation constant of Kd= 6.8 X10-10M.The binding of this antibody to human CD89 was confirmed with ELISA. This antibody was also capable of recognizing human CD89 expressing cells like human PMNL cells by flow cytometry. This antibody is not capable of blocking binding of IgA to CD89. This antibody can used to immunoprecipitate soluble CD89 (US7192582). A bispecific antibody construct incorporating the variable regions of the anti-gp41 antibody F240 and the anti-CD89 (immunoglobulin A [IgA] receptor) antibody 14A8 was reported to promote destruction of HIV type 1 (HIV-1) by neutrophils (PMID: 18272577). A Fab-like bispecific antibody molecule or Bi-Fab antibody generated from F240scFv and 14A8scFv showed significant antiboy dependent cell-mediated viral inhibition (ADCVI) activity for multiple clade B and clade C isolates by arming the neutrophils to inhibit HIV infection (PMID: 27419146).

Commentaires:

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Détails sur FCAR

Antigène: FCAR (Fc Fragment of IgA, Receptor For (FCAR))

Autre désignation: CD89

Sujet: Immunoglobulin alpha Fc receptor, FCAR, IgA Fc receptor, FcαR

UniProt: P24071