Recombinant Hemagglutinin anticorps

N° du produit ABIN7487730

L’anticorps anti-Hemagglutinin Monoclonal Human est utilisé pour la détection de Hemagglutinin dans des échantillons de Influenza A Virus. Il a été validé pour Neut.

Aperçu rapide pour Recombinant Hemagglutinin anticorps (ABIN7487730)

Antigène: Hemagglutinin (HA)

Type d'anticorp: Recombinant Antibody

Reactivité: Influenza A Virus

Hôte: Human

Clonalité: Monoclonal

Conjugué: Cet anticorp Hemagglutinin est non-conjugé

Application: Neutralization (Neut)

Clone: CR6261

Détail du produit anti-Hemagglutinin anticorps

Fonction: Anti-HA [CR6261], Human IgG1, kappa

Specificité:

This antibody binds hemaglutinin of most group 1 influenza viruses. CR6261 recognizes a highly conserved helical region in the membrane-proximal stem of HA1/HA2.

Application Notes original Clone: The antibody neutralizes the virus by blocking conformational rearrangements associated with membrane fusion. CR6261 neutralizes multiple influenza subtypes, including H1, H2, H5, H6, H8, and H9, and protects mice from lethal challenge with H1N1 and H5N1 viruses when administered up to five days post-infection (PMID: 19251591). It is reported that Oseltamivir/Zanamivir may congruously improve the therapeutic efficacy of CR6261 (PMID: 22693576).

Purification: Protein A affinity purified

Immunogène: The original antibody was isolated using phage display from the IgM+ memory B cells of a healthy individual vaccinated against influenza.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

OriginalSpeciesName: Human

OriginalFormat: IgG1

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Détails sur Hemagglutinin

Antigène: Hemagglutinin (HA)

Autre désignation: Hemagglutinin

Classe de substances: Influenza Protein

Sujet: Hemagglutinin, Avian Influenza Virus, AIV, H1N1, H5N1, Influenza A virus

UniProt: Q9WFX3