Recombinant KLRK1 anticorps

N° du produit ABIN7487747

Cet anticorps Souris Monoclonal détecte spécifiquement KLRK1 dans FACS et BP. Il présente une réactivité envers Humain.

Aperçu rapide pour Recombinant KLRK1 anticorps (ABIN7487747)

Antigène: KLRK1 (Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp KLRK1 est non-conjugé

Application: Flow Cytometry (FACS), Blocking Peptide (BP)

Clone: 6E5A7

Détail du produit anti-KLRK1 anticorps

Fonction: Anti-NKG2D [6E5A7], Mouse IgG2b, kappa

Specificité: This antibody recognizes and binds the extracellular epitope of NKG2D and blocks the interaction between ligand and receptor.

Attributs du produit:

Original Species of Ab: Mouse

Original Format of Ab: IgG2b

Purification: Protein A affinity purified

Immunogène: The original antibody was generated by immunizing BALB/c mice with soluble NKG2-D fragments containing amino acids from 64-462 and 123-462.

Isotype: IgG2b kappa

Information d'application

Indications d'application: The NKG2D (Natural Killer Group 2 Member D) protein is an activating receptor that enables NK and CD8 + T cells to recognize and eliminate infected or transformed endogenous cells. However, an incorrect regulation of this receptor on immune cells also appears to lead to the development of autoimmune diseases such as type I diabetes, celiac disease and RA.This antibody positively reacts with NKG2D on CD8-positive T cells and to CD56-positive natural killer cells. The binding was confirmed FACS analysis (Steigerwald, 2008).

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Détails sur KLRK1

Antigène: KLRK1 (Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1))

Autre désignation: NKG2D

Sujet: CD314, NKG2-D type II integral membrane protein, Killer cell lectin-like receptor subfamily K member 1, NK cell receptor D, NKG2-D-activating NK receptor, KLRK1

UniProt: P26718

Pathways: Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process