SIGLEC5 anticorps (Extracellular Domain) (APC)

N° du produit ABIN7505866

Détail du produit anti-SIGLEC5 anticorps (APC)

Antigène: SIGLEC5 (Sialic Acid Binding Ig-Like Lectin 5 (SIGLEC5))

Épitope: Extracellular Domain

Reactivité: Humain, Non-Human Primate

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SIGLEC5 est conjugé à/à la APC

Application: Flow Cytometry (FACS)

Fonction: Anti-Hu CD170 APC

Specificité: The mouse monoclonal antibody 1A5 recognizes an extracellular epitope of CD170 (Siglec-5, sialic acid binding Ig-like lectin 5), a transmembrane glycoprotein expressed strongly by neutrophils, macrophages activated during infections, monocytes, and dendritic cells. As in case with other anti-CD170 antibodies, this antibody crossreacts with Siglec-14, whose first two Ig domains are almost identical to those of CD170.

Purification: Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogène: Fusion protein composed of human CD170 extracellular domain and Fc region of human IgG1

Clone: 1A5

Isotype: IgG1

Information d'application

Indications d'application: Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.

Restrictions: For Research Use only

Stockage

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Détails sur SIGLEC5

Antigène: SIGLEC5 (Sialic Acid Binding Ig-Like Lectin 5 (SIGLEC5))

Autre désignation: CD170 (SIGLEC5 Produits)

Synonymes: anticorps CD170, anticorps CD33L2, anticorps OB-BP2, anticorps OBBP2, anticorps SIGLEC-5, anticorps sialic acid binding Ig like lectin 5, anticorps sialic acid-binding Ig-like lectin 5, anticorps sialic acid binding Ig-like lectin 5, anticorps SIGLEC5, anticorps LOC100597560, anticorps Siglec5

Sujet: Sialic acid binding Ig like lectin 5,CD170, also known as Siglec 5 (sialic acid binding Ig-like lectin 5) is a type 1 transmembrane glycoprotein containing two cytoplasmic immunoreceptor tyrosine inhibitory motifs (ITIMs). CD170 forms homodimers and functions as an inhibitory receptor able to downregulate cell activation. It binds to alpha2,3- and alpha2,6-linked sialic acid ligands, e.g. on glycophorin A (CD235a). Aberrant expression of CD170 by CD34+ progenitor cells can be observed in case of acute myeloid leukemias.,OBBP2, OB-BP2, SIGLEC-5, SIGLEC5

ID gène: 8778

UniProt: O15389