TREM1 anticorps

N° du produit ABIN7505920

Détail du produit anti-TREM1 anticorps

Antigène: TREM1 (Triggering Receptor Expressed On Myeloid Cells 1 (TREM1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TREM1 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), ELISA

Fonction: Anti-Hu CD354 Purified

Specificité: The mouse monoclonal antibody 6B1 (also known as 6B1.1G12) recognizes an extracellular epitope of human CD354 (TREM-1), a transmembrane glycoprotein, serving as an important innate immunity receptor.

Purification: Purified by protein-A affinity chromatography.

Immunogène: recombinant human CD354 fused with IgG

Clone: 6B1

Isotype: IgG1

Information d'application

Indications d'application: Flow cytometry: Recommended dilution: 1-4 μg/mL.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Détails sur TREM1

Antigène: TREM1 (Triggering Receptor Expressed On Myeloid Cells 1 (TREM1))

Autre désignation: CD354 (TREM1 Produits)

Synonymes: anticorps TREM1, anticorps CD354, anticorps TREM-1, anticorps triggering receptor expressed on myeloid cells 1, anticorps TREM1, anticorps Trem1, anticorps LOC100349504

Sujet: Triggering receptor expressed on myeloid cells 1,CD354 (TREM-1), a cell surface glycoprotein expressed mainly on monocytes, macrophages, and neutrophils, but also on e.g. endothelial cells or bronchial epithelium, plays an important role in innate immune responses. Upon triggering by its ligands (mainly bacterial and fungal components, but also some viruses, such as Marburg or Ebola virus), it initiates signaling cascades leading to release of pro-inflammatory cytokines and chemokines. CD354 is strongly present in infectious inflammatory lesions (e.g. in folliculitis or impetigo), but not so much in non-infectious inflammatory lesions, (e.g. vasculitis or psoriasis). However, under certain conditions neutrophils can upregulate CD354 also under non-infectious inflammatory conditions, e.g. in rheumatoid arthritis. Soluble CD354 (sTREM-1) is an important biomarker for identification of septic patients, as well as for prediction of their survival.,TREM-1

ID gène: 54210

UniProt: Q9NP99