TIAL1 anticorps

N° du produit ABIN7506023

Cet anticorps anti-TIAL1 Monoclonal Souris (Clone 6E3) (ABIN7506023) détecte spécifiquement TIAL1 dans WB, ELISA, IHC (p), FACS et ICC. L’anticorps est réactif avec des échantillons de Humain, Souris et Non-Human Primate.

Aperçu rapide pour TIAL1 anticorps (ABIN7506023)

Antigène: TIAL1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1 (TIAL1))

Reactivité: Humain, Souris, Non-Human Primate

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TIAL1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Clone: 6E3

Détail du produit anti-TIAL1 anticorps

Fonction: Anti-TIAR Purified

Specificité: The mouse monoclonal antibody 6E3 recognizes TIAR, an ubiquitously expressed approximately 42 kDa intracellular RNA-binding protein.

Purification: Purified by protein-A affinity chromatography.

Immunogène: GST-tagged recombinant human TIAR

Isotype: IgG2a kappa

Information d'application

Indications d'application: Flow cytometry: Intracellular staining, recommended dilution: 5 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Détails sur TIAL1

Antigène: TIAL1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1 (TIAL1))

Autre désignation: TIAR

Sujet: TIA1 cytotoxic granule associated RNA binding prot,TIAR is an ubiquitously expressed RNA-binding protein, which regulates translational control, splicing, and other activities, including apoptosis. TIAR attenuates CDK1 activity, and is essential for the G2/M checkpoint. It accumulates in nuclear foci in late G2 phase and prophase in cells under replication stress. In steady state TIAR shuttles between the cytoplasm and the nucleus, probably as a part of nucleocytoplasmic transport of mRNA, but under stress conditions it accumulates mRNA molecules in granules and prevents their translation. Nucleolytic activity of TIAR against attacked target cells of cytotoxic lymphocytes has also been reported. Similarly, e.g. in permeabilized thymocytes TIAR triggers DNA fragmentation.,TCBP, TIAL1

ID gène: 7073

UniProt: Q01085