Recombinant EGFR (Margetuximab Biosimilar) anticorps
Aperçu rapide pour Recombinant EGFR (Margetuximab Biosimilar) anticorps (ABIN7538064)
Antigène
Type d'anticorp
Reactivité
Hôte
Clonalité
Conjugué
Application
Classe de qualité
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Expression System
- Mammalian cells
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Fonction
- Margetuximab Biosimilar - Anti-ERBB2, EGFR2, CD340 mAb - Research Grade
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Attributs du produit
- Antibody Type: IgG1-kappa
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Purification
- Recombinant antibody expressed in mammalien cells and purified.
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Pureté
- > 85%
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Isotype
- IgG1 kappa
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Restrictions
- For Research Use only
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Buffer
- PBS buffer PH7.5
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Stock
- -80 °C
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Stockage commentaire
- store at -80°C
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- EGFR (Margetuximab Biosimilar)
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Classe de substances
- Biosimilar
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Sujet
- Margetuximab is an Fc-engineered human/mouse chimeric anti-HER2 monoclonal antibody of isotype IgG1 kappa . Margetuximab targets the same epitope on the HER2 extracellular domain and hass the same activity as trastuzumab. However, margetuximab has a higher affinity for both CD16A variants and a weaker one to the inhibitory CD32B Fc receptor, thereby resulting in more efficient antibody-dependent cell-mediated cytotoxicity (ADCC) and higher efficacy compared to trastuzumab.
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Numéro CAS
- 1350624-75-7
Antigène
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