L’anticorps anti-EGFR (Margetuximab Biosimilar) Chimeric Human est utilisé pour la détection de EGFR (Margetuximab Biosimilar) dans des échantillons de Humain. Il a été validé pour ELISA et WB.
Research Grade
Reactivité: Humain
Hôte: Chimeric
Chimeric
unconjugated
Recombinant Antibody
Restrictions
For Research Use only
Buffer
PBS buffer PH7.5
Stock
-80 °C
Stockage commentaire
store at -80°C
Antigène
EGFR (Margetuximab Biosimilar)
Classe de substances
Biosimilar
Sujet
Margetuximab is an Fc-engineered human/mouse chimeric anti-HER2 monoclonal antibody of isotype IgG1 kappa . Margetuximab targets the same epitope on the HER2 extracellular domain and hass the same activity as trastuzumab. However, margetuximab has a higher affinity for both CD16A variants and a weaker one to the inhibitory CD32B Fc receptor, thereby resulting in more efficient antibody-dependent cell-mediated cytotoxicity (ADCC) and higher efficacy compared to trastuzumab.