C3b/iC3b anticorps

N° du produit ABIN7540410

L’anticorps anti-C3b/iC3b Monoclonal Souris est utilisé pour la détection de C3b/iC3b dans des échantillons de Humain et Non-Human Primate. Il a été validé pour FACS, ELISA, ICC et RIA.

Aperçu rapide pour C3b/iC3b anticorps (ABIN7540410)

Antigène: C3b/iC3b

Reactivité: Humain, Non-Human Primate

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Inconjugué

Application: Flow Cytometry (FACS), ELISA, Immunocytochemistry (ICC), Radioimmunoassay (RIA)

Clone: 3E7

Détail du produit

Fonction: Anti-Hu C3b/iC3b Purified

Attributs du produit: The mouse monoclonal antibody 3E7 recognizes complement component C3b and iC3b. It does not cross-react with C3d.

Purification: Purified by protein-A affinity chromatography.

Immunogène: human complement component C3b

Isotype: IgG1, kappa

Information d'application

Indications d'application: Flow cytometry: Recommended dilution: 0.5-4 μg/mL.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Détail du antigène

Antigène: C3b/iC3b

Sujet:

NCBI Full Gene Name: complement C3

Description: Complement component C3 plays a key role in the activation of complement system. In classical complement system pathway the activated C2 and C4 form classical C3-convertase (C4b2b) which cleaves C3 into C3a and C3b. In alternative complement system pathway C3 is cleaved by alternative C3-convertase (C3bBb), composed of C3b (which can be generated also by spontaneous hydrolysis of C3) and the activated form of factor B. C3b activates downstream cascade leading to formation of pores in the plasma membrane of attacked cell. C3b and its proteolytically inactive form iC3b also serve as important opsonins. C3b can generate C3f, as well as the iC3b can be further cleaved into C3c, C3d and C3g. Complement system is regulated by effective inactivation of free C3b by factor H and factor I. C3b attached to the surface of its target is protected from this inactivation. Complement system is also regulated by other proteins, e.g. CD35, CD46, CD55, or CD59. Undesired activation of complement cascade can lead to severe diseases such as PNH, rheumatoid arthritis, macular degeneration and other. Recently it has been demonstrated to take part in complications associated with Covid-19.

Other names: complement component C3, complement component C3b, complement component iC3b

Gene name: C3

ID gène: 718

UniProt: P01024