EBV LMP1 anticorps

N° du produit ABIN7540659

N° du produit (Fournisseur): mob194-01

L’anticorps Souris Monoclonal anti-EBV LMP1 a été validé pour IHC. Il convient pour détecter EBV LMP1 dans des échantillons de Epstein-Barr Virus (EBV).

Aperçu rapide pour EBV LMP1 anticorps (ABIN7540659)

Antigène: EBV LMP1 (Epstein-Barr Virus Latent Membrane Protein 1 (EBV LMP1))

Reactivité: Epstein-Barr Virus (EBV)

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp EBV LMP1 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: CS1-CS2-CS3-CS4

Détail du produit anti-EBV LMP1 anticorps

N° du produit (Fournisseur): mob194-01

Fournisseur: Rockland

Fonction: LMP-1 (Epstein-Barr Virus) Monoclonal Antibody

Réactivité croisée (Details): This antibody is specific to 60 kDa latent membrane protein (LMP-1) encoded by the BNLF1 gene of the EBV.

Purification: The antibody was clarified from tissue culture supernatant.

Immunogène: Anti-LMP-1 (Epstein-Barr Virus) antibody was produced in mice by repeated immunizations with recombinant fusion protein containing sequences of bacterial beta-galactosidase and EBV encoded latent membrane protein.

Isotype: IgG1

Information d'application

Indications d'application: Optional[Neutralization_Dilution]: 1:50-1:100

Commentaires:

Anti-LMP-1 (Epstein-Barr Virus) (MOUSE) Monoclonal Antibody was tested in IHC-P with positive control infected lymphoblastoma, Hodgkin's lymphoma tissues. Cellular Localization: Cytoplasmic. The user is advised to validate the use of the products with their tissue specimens prepared and handled in accordance with their laboratory practices. This antibody stains strongly with EBV positive lymphoblastoid cell lines and EBV infected B cell immunoblasts in infectious mononucleosis. Consult references (Kiernan, 1981: Sheehan & Hrapchak, 1980) for further details on specimen preparation.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.01 % (w/v) Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. This antibody is suitable for use until the expiration date when stored at 2-8°C. Do not use product after the expiration date printed on vial. If reagents are stored under conditions other than those specified here, they must be verified by the user. Diluted reagents should be used promptly. Unused portions of antibody preparation should be discarded after one day. The presence of precipitate or an unusual odor indicates that the antibody is deteriorating and should not be used.

Détails sur EBV LMP1

Antigène: EBV LMP1 (Epstein-Barr Virus Latent Membrane Protein 1 (EBV LMP1))

Autre désignation: EBV LMP-1

Classe de substances: Viral Protein

Sujet: Epstein-Barr Virus, EBV, Latent Membrane Protein 1, Human herpesvirus 4, HHV-4,Latent membrane protein 1 acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation. It functions as a constitutively active tumor necrosis factor receptor that induces the activation of several signaling pathways, including those of the NF-kappa-B family. LMP1 signaling leads to up-regulation of antiapoptotic proteins and provide growth signals in latently infected cells. It interacts with host UBE2I and subsequently affects the sumoylation state of several cellular proteins. For example, LMP1 induces the sumoylation of host IRF7 thereby limiting its transcriptional activity and modulating the activation of innate immune responses.