Recombinant CD20 anticorps

N° du produit ABIN7543098

L’anticorps Human Chimeric anti-CD20 a été validé pour WB. Il convient pour détecter CD20 dans des échantillons de Humain.

Aperçu rapide pour Recombinant CD20 anticorps (ABIN7543098)

Antigène: CD20 (MS4A1) (Membrane-Spanning 4-Domains, Subfamily A, Member 1 (MS4A1))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Human

Clonalité: Chimeric

Conjugué: Cet anticorp CD20 est non-conjugé

Application: Western Blotting (WB)

Clone: B9E9

Détail du produit anti-CD20 anticorps

Fonction: Anti-CD20 [B9E9], Human IgG1, kappa

Specificité: This antibody is specific for CD20, which is expressed by normal and malignant B cells. It does not cross-react with murine CD20.

Attributs du produit:

Original Species of Ab: Mouse

Original Format of Ab: IgG2a

Purification: Protein A affinity purified

Immunogène: This antibody was raised against human CD20.

Isotype: IgG1 kappa

Information d'application

Indications d'application: This antibody has been used in western blot detection of CD20 in human plasma, revealing elevated CD20 levels in plasma from chronic lymphocytic leukemia patients (Manshouri et al, 2003). An scFv derived from this antibody fused to streptavidin has been investigated as a method of pretargeted radioimmunotherapy for lymphomas (Schultz et al, 2000), and has been demonstrated to be non-toxic in a phase I trial of non-Hodgkin lymphoma patients (Forero et al, 2004). Additionally, measles viruses engineered to express this scFv are able to enter CD20+ target cells through interaction with CD20 antigen, with clinical relevance for lymphoma therapy (Bucheit et al, 2003).

Commentaires:

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Détails sur CD20

Antigène: CD20 (MS4A1) (Membrane-Spanning 4-Domains, Subfamily A, Member 1 (MS4A1))

Autre désignation: CD20

Sujet: MS4A1, B-lymphocyte antigen CD20,MS4A1, B-lymphocyte surface antigen B1, Bp35, Leukocyte surface antigen Leu-16, Membrane-spanning 4-domains subfamily A member 1, E9PPL6, P19437

UniProt: P11836